Murraya koenigii Extract Loaded Phytosomes Prepared using Antisolvent Precipitation Technique for Improved Antidiabetic and Hypolidemic Activity

Abstract: Background: Phytosome is a novel technique introduced by Indena that combines standardised herbal extract and phospholipid in preferably equal ratio to provide better absorption enhancing bioavailability. Purpose: The objective of proposed study prepare, optimise characterize phytosomes Murraya koenigii (Linn.) Spreng improve its antidiabetic properties. Materials Methods: Antisolvent precipitation was used prepare phytosomes. Design expert software evaluate the impact soya lecithin cholesterol concentration on various dependent variables such as particle size, span value entrapment efficiency. Streptozotocin-nicotinamide induced diabetes model vivo activity rats for well prepared Results: were successfully designed optimised efficiency, value, zeta potential 236 nm, 75.1%, 0.395 -16.85 mV respectively. Streptozotocinnicotinamide plant extracts optimized phytosomal formulations male Wistar rats. Optimized formulation showed significant reduction serum glucose at lower dose, suggesting enhancement therapeutic efficacy. Conclusion: We successful formulation, optimization characterization extract. tested hypolipidemic activities compared crude Key words: koenigii, Phytosomes, Antidiabetics, Herbal